#153 … we couldn’t keep the mice from losing weight! – Krista Varady

#196 But as hard as we tried, we couldn’t keep the mice from losing weight! – Krista Varady
QUOTE “Under the guidance of my advisor, Dr. Marc Hellerstein, I investigated the effect of calorie restriction on cancer. There was already a lot of research on calorie restriction and longevity in animals; it showed that when mice are fed less food, they live up to twice as long as mice fed a normal diet. Furthermore, some of the biochemical mechanisms triggered by calorie restriction in longevity research are known to be anticancer. The mechanisms include slower cell division; lower levels of IGF-1 (insulin-like growth factor 1, a growth factor that stimulates cancer cells to divide and multiply); and lower levels of glucose, the main fuel for cancer cells. Our research question was this: Can you put a mouse on the ultimate form of calorie restriction—fasting—so that the growth of cancer cells is slowed, but the animal does not lose weight? (In their research, scientists are always trying to isolate and analyze specific factors. In this case, we wanted to isolate the effect of calorie restriction on cancer from the effect of weight loss on cancer.) But as hard as we tried, we couldn’t keep the mice from losing weight! We fasted them one day and let them eat all they wanted the next day. But they never ate enough calories on “feed day” to fully compensate for the total lack of calories on “fast day.” Sometimes they managed to eat 150% of a normal day’s calories on feed day. Sometimes they ate up to 170%. But they never ate 200% of their normal caloric intake on feed day to make up for the zero calories on fast day. And so they always lost weight.” [1]

“My experiment had failed because there was no way to separate the effect of calorie restriction from the effect of weight loss. I was not a happy scientist! But a scientific investigation that seems like a dead end can suddenly present a new vista of opportunity. And that’s just what happened: I had a eureka moment, an Aha!, a conceptual breakthrough when I realized that the mice always lost weight on alternate-day fasting. The mice always lost weight. Could alternate-day fasting help us humans lose weight?” [2]

NOTE – What does it say?

My takeaway:

What gets your attention?
What human needs or problems are addressed?
What questions do you have?
What solution or hope does it offer?

What does it say that we need to obey?
What would a camera see if this happened?
Who needs to hear this?
What are the actual steps that I would take?
[1] Quote from “The Every-Other-Day Diet: The Diet That Lets You Eat All You Want (Half the Time) and Keep the Weight Off” by Krista Varady and Bill Gottlieb.
[2] Ibid, ?.
Image by Arek Socha from Pixabay.
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